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Search Results for " protease-activated receptor-1 antagonist 1 "

10

Compounds

Cat No. Product Name Synonyms Targets
T62507 Protease-Activated Receptor-1 antagonist 1
Protease-Activated Receptor-1 antagonist 1 (Compound 13) is a protease-activated receptor 1 (PAR-1) antagonist with an IC50 of 3 nM obtained by the FLIPR technique. antagonist 1 can be used to study thrombotic cardiovasc...
T64285 Protease-Activated Receptor-1 antagonist 2
Protease-Activated Receptor-1 antagonist 2 is a selective, orally active protease-activated receptor-1 (PAR-1) antagonist (IC50: 7 nM). It has shown good pharmacokinetic properties and can be used for studies related to ...
T63382 Protease-Activated Receptor-1 antagonist 3
Protease-Activated Receptor-1 antagonist 3 is a potent antagonist (IC50: 7 nM) of Protease-Activated Receptor 1protease-activated receptor-1. antagonist 3 exhibits binding affinity to hERG K+ channels (IC50: 9 μM).
T74266 Protease-Activated Receptor-1 antagonist 2
Protease-Activated Receptor-1 Antagonist 2 is an orally active antagonist of protease-activated receptor-1 (PAR-1), demonstrating significant potency with an IC 50 of 7 nM. It exhibits favorable pharmacokinetic character...
T12870 SCH79797 dihydrochloride Apoptosis , Others , Protease-activated Receptor
SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects.
T22792 FR-171113 Others
Protease-activated receptor 1 antagonist
T23282 RWJ-56110 Others
protease-activated receptor-1 (PAR1) antagonist
T14684 BMS-986120 Others
BMS-986120 is a first-in-class oral and reversible protease-activated receptor 4 (PAR4) antagonist. With IC50s of 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatele...
T60854 ENMD-1068 hydrochloride
ENMD-1068 hydrochloride, a selective protease-activated receptor 2 (PAR2) antagonist, inhibits TGF-β1/Smad signaling, thereby reducing hepatic stellate cell activation and collagen expression. It also suppresses the prol...
T36717 RWJ-56110 dihydrochloride
RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits...
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